反复不良妊娠结局的
免疫抑制剂治疗

flowchart TD A["患者评估"] --> B{"RPL类型"} B -->|早期流产| C["免疫异常筛查"] B -->|晚期流产| D["APS/解剖因素"] B -->|FGR| E["胎盘功能评估"] B -->|PE| F["风险分层"] C --> G{"免疫指标"} G -->|Tregs缺陷| H["糖皮质激素"] G -->|Th1/Th2失衡| I["糖皮质激素/IVIG"] G -->|NK细胞异常| J["糖皮质激素/IVIG"] G -->|无异常| K["经验性治疗"] D --> L["抗凝治疗"] D --> M["羟氯喹"] D --> N["糖皮质激素"] E --> O["小剂量阿司匹林"] E --> P["改善胎盘灌注"] F --> Q["低剂量阿司匹林"] F --> R["羟氯喹"] H --> S["动态监测"] I --> S J --> S K --> S L --> S M --> S N --> S O --> S P --> S Q --> S R --> S S --> T["剂量调整"] T --> U["分娩计划"] style A fill:#f6f7f6,stroke:#5c7a5c,stroke-width:2px,color:#2b372b style B fill:#ffffff,stroke:#5c7a5c,stroke-width:2px,color:#2b372b style C fill:#e6f3ff,stroke:#4a90e2,stroke-width:2px,color:#1a5490 style D fill:#fff4e6,stroke:#f5a623,stroke-width:2px,color:#8c5a1f style E fill:#f0f8ff,stroke:#7ed321,stroke-width:2px,color:#4a7c59 style F fill:#f9f0ff,stroke:#9013fe,stroke-width:2px,color:#5c3a8c style G fill:#ffffff,stroke:#5c7a5c,stroke-width:2px,color:#2b372b style H fill:#d4edda,stroke:#28a745,stroke-width:2px,color:#1e4620 style I fill:#d4edda,stroke:#28a745,stroke-width:2px,color:#1e4620 style J fill:#d4edda,stroke:#28a745,stroke-width:2px,color:#1e4620 style K fill:#fff3cd,stroke:#ffc107,stroke-width:2px,color:#856404 style L fill:#cce5ff,stroke:#004085,stroke-width:2px,color:#002752 style M fill:#b3d7ff,stroke:#0066cc,stroke-width:2px,color:#003366 style N fill:#b3d7ff,stroke:#0066cc,stroke-width:2px,color:#003366 style O fill:#d1ecf1,stroke:#0c5460,stroke-width:2px,color:#0c525d style P fill:#d1ecf1,stroke:#0c5460,stroke-width:2px,color:#0c525d style Q fill:#f8d7da,stroke:#721c24,stroke-width:2px,color:#721c24 style R fill:#f8d7da,stroke:#721c24,stroke-width:2px,color:#721c24 style S fill:#fff2cc,stroke:#b08d69,stroke-width:2px,color:#5a453c style T fill:#e2e3e5,stroke:#383d41,stroke-width:2px,color:#383d41 style U fill:#d4edda,stroke:#28a745,stroke-width:3px,color:#1e4620